BDBM50096279 CHEMBL3577124
SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C
InChI Key InChIKey=UIJRICRAFILDOG-SNAWJCMRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50096279
Affinity DataKi: 0.139nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.139nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) inactive MAP2K1 as substrate preincubated for 30 mins measured after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type BRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Competitive binding affinity to EphA2 in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of desthiobiotin-ATP acylphosphate probe binding to B-Raf in human A375 cells by MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human GST-tagged BRAF V600E mutant (416 to 766 residues) using human full length 6His-tagged MEK1 (K97R) as substrate preincubated for ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as inhibition of ERK phosphorylation measured after 72 hrs by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Competitive binding affinity to BRAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair